CYP11A1 is also expressed in other steroid hormone-producing organs. One example is CYP11A1 which converts cholesterol to pregnenolone. Small amounts of sex hormones are also released from the adrenal gland but mainly produced in other organs (testis and ovaries). Mineralocorticoids are involved in the control of electrolyte balance and blood pressure. Glucocorticoids regulate the body's metabolic processes and stress response. The hormones released from the adrenal cortex are vital to life. Proteins specifically expressed in the adrenal cortex In-depth analysis of the elevated genes in the adrenal gland using antibody-based protein profiling allowed us to visualize where these proteins are expressed with regards to localization in the adrenal cortex and adrenal medulla. Protein expression of genes elevated in adrenal gland Glycosylphosphatidylinositol anchored molecule likeĬytochrome P450 family 21 subfamily A member 2Ĭytochrome P450 family 11 subfamily A member 1

Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 GeneĬytochrome P450 family 11 subfamily B member 1Ĭytochrome P450 family 11 subfamily B member 2Ĭytochrome P450 family 17 subfamily A member 1 'Tissue specificity score (TS)' corresponds to the fold-change between the expression level in adrenal gland and the tissue with the second-highest expression level. 'mRNA (tissue)' shows the transcript level in adrenal gland as nTPM values. 'Tissue distribution' describes the transcript detection (nTPM≥1) in adrenal gland as well as in all other tissues. The 12 genes with the highest level of enriched expression in adrenal gland. Detected in all: Detected in all tissues.Detected in many: Detected in at least a third but not all tissues.Detected in some: Detected in more than one but less than one-third of tissues.Detected in single: Detected in a single tissue.As evident in Table 1, all genes elevated in adrenal gland are categorized as: Tissue enhanced: At least four-fold higher mRNA level in adrenal gland compared to the average level in all other tissues.ĭistribution, on the other hand, visualizes how many genes have, or do not have, detectable levels (nTPM≥1) of transcribed mRNA molecules in the adrenal gland compared to other tissues.Group enriched: At least four-fold higher average mRNA level in a group of 2-5 tissues compared to any other tissue.

Tissue enriched: At least four-fold higher mRNA level in adrenal gland compared to any other tissues.

Elevated expression includes three subcategory types of elevated expression: Specificity illustrates the number of genes with elevated or non-elevated expression in the adrenal gland compared to other tissues.

Transcriptome analysis of the adrenal gland can be visualized with regard to the specificity and distribution of transcribed mRNA molecules (Figure 1).

Adrenal gland cortex hormones